SCUBE2

Across TCGA pan-cancer cohorts, SCUBE2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SCUBE2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SCUBE2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SCUBE2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, HNSC, and UCEC are the cancer types where SCUBE2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.949	0.898	<.001	97	view →
HNSC	DFS	Quartile	All	0.760	0.570	<.001	85	view →
UCEC	DFS	Tertile	All	0.924	0.853	.003	40	view →
KIRP	DFS	Tertile	All	0.612	1.000	.002	34	view →
STAD	DFS	Median	All	0.330	0.471	.008	27	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.117	.006	27	view →
CESC	OS	Tertile	All	0.842	0.691	.008	26	view →
SCLC	DFS	Quartile	All	0.665	0.389	.005	19	view →
COAD	OS	Tertile	IV	0.815	0.387	.001	19	view →
THCA	OS	Median	All	0.833	1.000	.011	16	view →
ACC	OS	Quartile	II,III,IV	0.262	0.884	.009	16	view →
UVM	DFS	Quartile	III,IV	0.286	0.664	.018	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SCUBE2–BRCA (OS)

Open the BRCA breakdown →