SCUBE2

Across TCGA patient cohorts, SCUBE2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCUBE2-associated genes across cancer lineages are ASNS, ATM, and FASN. Each is linked with SCUBE2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCUBE2-to-partner and partner-to-SCUBE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SCUBE2-low versus SCUBE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE2→partner) and Y-score (partner→SCUBE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.279	+1.662	.013	.010	3	4
COAD	ATM →	-0.558	-3.169	.001	.017	3	3
COAD	FASN →	+0.639	+3.169	<.001	.018	3	2
UCEC	MEK1 →	+0.329	+2.247	.003	.001	3	2
COAD	PKC-b-II_pS660 →	-0.427	-3.169	.007	.018	3	2
COAD	Stathmin →	+0.142	+2.820	.040	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ASNS by SCUBE2 expression — UCEC

Explore this box plot interactively →