SCUBE2

Across TCGA cell cohorts, SCUBE2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCUBE2-associated genes across cancer lineages are GPX5, OR2D3, and OR51J1. Each is linked with SCUBE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCUBE2-to-partner and partner-to-SCUBE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX5 grouped by SCUBE2-low versus SCUBE2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE2→partner) and Y-score (partner→SCUBE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPX5 →	+0.199	+2.688	<.001	.008	3	2
LIVER	OR2D3 →	+0.052	+4.459	<.001	.001	3	1
LIVER	OR51J1 →	+0.228	+3.977	<.001	.006	3	1
LIVER	OR51B2 →	+0.305	+3.977	<.001	.006	3	1
SOFT_TISSUE	FCRL2 →	+0.020	+3.450	.001	<.001	3	1
SOFT_TISSUE	NLRP7 →	+0.111	+3.579	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GPX5 by SCUBE2 expression — LARGE_INTESTINE

Explore this box plot interactively →