SCUBE1-AS2

Across TCGA pan-cancer cohorts, SCUBE1-AS2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SCUBE1-AS2 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SCUBE1-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCUBE1-AS2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THYM show a favorable association.

BLCA, ACC, and LUSC are the cancer types where SCUBE1-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.337	0.642	<.001	120	view →
ACC	DFS	Tertile	All	0.198	0.709	<.001	46	view →
LUSC	OS	Tertile	All	0.698	0.786	.010	45	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	36	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	36	view →
DLBC	DFS	Tertile	All	0.386	0.855	.006	32	view →
KIRC	DFS	Tertile	IV	0.318	0.626	.027	30	view →
ESCA	DFS	Median	III,IV	0.544	0.254	.011	18	view →
LGG	DFS	Tertile	All	0.231	0.421	.010	15	view →
THYM	DFS	Tertile	II,III,IV	0.963	0.785	.013	11	view →
UVM	OS	Tertile	III,IV	0.452	0.929	.017	9	view →
BRCA	OS	Quartile	III,IV	0.969	0.870	.010	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SCUBE1-AS2–BLCA (DFS)

Open the BLCA breakdown →