SCUBE1-AS2

Across TCGA pan-cancer cohorts, SCUBE1-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SCUBE1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SCUBE1-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCUBE1-AS2 is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.

BRCA, LUSC, and KIRC are the cancer types where SCUBE1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCUBE1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.520	<.001	6	view →
LUSC	All	All	−0.188	.004	5	view →
KIRC	All	All	−0.048	<.001	5	view →
KIRP	All	All	−0.091	.002	4	view →
THCA	Male	All	−0.111	.026	3	view →
UCEC	All	All	−0.471	.005	2	view →
LUAD	Female	All	−0.241	.044	2	view →
KICH	Female	All	−0.143	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SCUBE1-AS2–BRCA

Open the BRCA breakdown →