Across TCGA pan-cancer cohorts, SCUBE1-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SCUBE1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SCUBE1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCUBE1-AS1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

LIHC, BRCA, and KIRC are the cancer types where SCUBE1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCUBE1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.012	<.001	5	view →
BRCA	All	II,III,IV	+0.031	.012	4	view →
KIRC	Male	All	−0.010	.004	4	view →
KIRP	All	All	−0.013	.002	3	view →
LUSC	Male	All	−0.014	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SCUBE1-AS1 RNA expression & survival · all SCUBE1-AS1 data types