SCRN3

Across TCGA patient cohorts, SCRN3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCRN3-associated genes across cancer lineages are ASNS, 4E-BP1, and 14-3-3_beta. Each is linked with SCRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCRN3-to-partner and partner-to-SCRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SCRN3-low versus SCRN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRN3→partner) and Y-score (partner→SCRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.451	+1.584	<.001	.032	3	2
UCEC	4E-BP1 →	+0.255	+3.169	.010	.018	3	2
UCEC	14-3-3_beta →	-0.120	-1.886	.001	.015	3	1
UCEC	EGFR_pY1068 →	-0.257	-1.847	.005	.008	3	1
UCEC	EGFR →	-0.191	-2.000	.001	.030	3	1
UCEC	eIF4E →	+0.201	+3.335	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by SCRN3 expression — UCEC

Explore this box plot interactively →