SCRN3

Across TCGA pan-cancer cohorts, SCRN3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SCRN3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SCRN3 RNA is repressed in tumor relative to normal tissue. In most cancer types SCRN3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where SCRN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCRN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.052	<.001	9	view →
KICH	Female	All	−1.185	<.001	6	view →
BRCA	All	II,III,IV	+0.244	<.001	6	view →
LIHC	Male	All	+0.698	<.001	5	view →
BLCA	Female	All	+0.463	.025	4	view →
LUSC	All	All	+0.333	.001	4	view →
CHOL	All	All	+1.248	<.001	2	view →
UCEC	All	All	−0.573	.001	2	view →
ESCA	Female	All	+0.970	<.001	1	view →
BLCA	Male	IV	−0.652	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

SCRN3–THCA

Open the THCA breakdown →