SCP2D1

Across TCGA patient cohorts, SCP2D1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCP2D1-associated genes across cancer lineages are JNK_pT183_Y185, STAT3_pY705, and Caspase-8. Each is linked with SCP2D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCP2D1-to-partner and partner-to-SCP2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SCP2D1-low versus SCP2D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCP2D1→partner) and Y-score (partner→SCP2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.218	-2.999	.010	.035	3	2
UCEC	STAT3_pY705 →	-0.501	-3.169	<.001	.018	3	2
UCEC	Caspase-8 →	-0.306	-3.295	.015	.009	3	2
UCEC	EGFR_pY1068 →	-0.281	-2.321	.026	.035	3	1
UCEC	mTOR_pS2448 →	-0.189	-2.980	.011	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.533	-2.321	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

JNK_pT183_Y185 by SCP2D1 expression — UCEC

Explore this box plot interactively →