SCNN1G

Across TCGA patient cohorts, SCNN1G mutation is significantly associated with the RNA expression of many other genes, with 3,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1G-associated genes across cancer lineages are REEP4, RPL31P9, and CCDC137. Each is linked with SCNN1G in more than 2 cancer types. Because this analysis shows association rather than direction, both SCNN1G-to-partner and partner-to-SCNN1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REEP4 grouped by SCNN1G-low versus SCNN1G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1G→partner) and Y-score (partner→SCNN1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	REEP4 →	+0.574	+2.546	<.001	<.001	3	3
UCEC	RPL31P9 →	+0.104	+2.547	<.001	.004	3	3
UCEC	CCDC137 →	+0.316	+1.506	.005	.004	3	3
UCEC	ICMT →	+0.350	+2.151	.002	.002	3	3
SKCM	PSMB2 →	+0.227	+1.366	.008	.003	3	3
UCEC	TAF9 →	+0.671	+2.222	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,928 associations by consensus.

REEP4 by SCNN1G expression — UCEC

Explore this box plot interactively →