SCNN1G

Across TCGA pan-cancer cohorts, SCNN1G RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SCNN1G data layer compared with 11 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SCNN1G RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SCNN1G expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

SKCM, KIRC, and LGG are the cancer types where SCNN1G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.710	0.831	<.001	92	view →
KIRC	DFS	Tertile	All	0.545	0.704	<.001	61	view →
LGG	DFS	Median	All	0.661	0.805	<.001	50	view →
UVM	DFS	Tertile	All	0.441	0.837	.007	42	view →
BLCA	OS	Median	II,III,IV	0.756	0.658	.005	35	view →
KIRP	OS	Median	II,III,IV	0.726	0.907	.005	28	view →
LUAD	DFS	Quartile	III,IV	0.826	0.341	.001	28	view →
HNSC	OS	Median	All	0.716	0.606	.009	23	view →
LIHC	DFS	Quartile	III,IV	0.112	0.270	.001	20	view →
ACC	OS	Median	IV	0.287	0.799	.006	17	view →
UCS	OS	Quartile	All	0.308	0.786	.001	16	view →
MESO	OS	Median	II,III,IV	0.209	0.370	.024	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SCNN1G–SKCM (OS)

Open the SKCM breakdown →