SCNN1G

Across TCGA cell cohorts, SCNN1G mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCNN1G-associated genes across cancer lineages are LY2109761, alpha-lipoic acid, and Fedratinib. Each is linked with SCNN1G in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1G-to-partner and partner-to-SCNN1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY2109761 grouped by SCNN1G-low versus SCNN1G-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1G→partner) and Y-score (partner→SCNN1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LY2109761 →	+0.370	+2.868	.019	.022	3	1
LARGE_INTESTINE	alpha-lipoic acid →	+0.372	+2.684	.008	.035	3	1
LARGE_INTESTINE	Fedratinib →	+0.623	+2.874	.011	.021	3	1
LARGE_INTESTINE	T0901317 →	+0.286	+2.944	.028	.018	3	1
LARGE_INTESTINE	IWP-2 →	+0.349	+3.115	.004	.015	2	1
LARGE_INTESTINE	GSK-LSD1 →	+0.277	+2.871	.045	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

LY2109761 by SCNN1G expression — LARGE_INTESTINE

Explore this box plot interactively →