SCNN1D

Across TCGA patient cohorts, SCNN1D mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1D-associated genes across cancer lineages are Smad3, C-Raf, and NF2. Each is linked with SCNN1D in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1D-to-partner and partner-to-SCNN1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad3 grouped by SCNN1D-low versus SCNN1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1D→partner) and Y-score (partner→SCNN1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad3 →	+0.236	+3.000	.004	.036	3	2
UCEC	C-Raf →	+0.273	+3.169	<.001	.020	3	2
UCEC	NF2 →	+0.381	+3.169	.001	.020	3	1
UCEC	p62 Lck ligand →	+0.477	+2.817	.007	.036	3	1
UCEC	PCNA →	+0.359	+3.169	.002	.020	3	1
UCEC	Annexin-1 →	+0.753	+3.169	.009	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Smad3 by SCNN1D expression — UCEC

Explore this box plot interactively →