SCNN1D

Across TCGA cell cohorts, SCNN1D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,578 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCNN1D-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Cellular response to aldosterone, and Negative regulation of myoblast fusion. Each is linked with SCNN1D in more than 14 cancer types. Because this analysis shows association rather than direction, both SCNN1D-to-partner and partner-to-SCNN1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by SCNN1D-low versus SCNN1D-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1D→partner) and Y-score (partner→SCNN1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Calcium-independent cell-matrix adhesion →	+0.273	+0.916	<.001	<.001	3	15
STOMACH	Cellular response to aldosterone →	-0.507	-1.163	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.164	+1.557	.001	<.001	3	13
LUNG_NSCLC_LUSC	Protein polyglycylation →	+1.334	+0.871	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.133	-1.061	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.168	+1.011	<.001	.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,578 associations by consensus.

Calcium-independent cell-matrix adhesion by SCNN1D expression — LARGE_INTESTINE

Explore this box plot interactively →