SCNN1A

Across TCGA pan-cancer cohorts, SCNN1A Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SCNN1A data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SCNN1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCNN1A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCS, and KICH are the cancer types where SCNN1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ACC	DFS	Median	All	0.068	0.667	.005	12	view →
GBM	OS	Median	All	0.062	0.416	.001	6	view →
ESCA	DFS	Median	All	0.098	0.533	.003	6	view →
UCEC	DFS	Median	All	0.947	0.623	.045	2	view →
SKCM	OS	Median	III,IV	1.000	0.801	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SCNN1A–THYM (OS)

Open the THYM breakdown →