SCN9A

Across TCGA patient cohorts, SCN9A mutation is significantly associated with the RNA expression of many other genes, with 6,733 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN9A-associated genes across cancer lineages are CDCA4, ARMCX2, and PSMD14. Each is linked with SCN9A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN9A-to-partner and partner-to-SCN9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA4 grouped by SCN9A-low versus SCN9A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN9A→partner) and Y-score (partner→SCN9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDCA4 →	+0.418	+1.236	<.001	<.001	3	5
BLCA	ARMCX2 →	-1.595	-3.416	<.001	.005	3	5
UCEC	PSMD14 →	+0.304	+1.508	<.001	<.001	3	5
SKCM	NFATC2 →	-0.639	-0.980	<.001	<.001	3	5
UCEC	LINC00869 →	-0.403	-1.595	<.001	<.001	3	4
UCEC	KIFC1 →	+0.480	+1.497	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,733 associations by consensus.

CDCA4 by SCN9A expression — SKCM

Explore this box plot interactively →