SCN9A

Across TCGA pan-cancer cohorts, SCN9A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SCN9A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SCN9A RNA is repressed in tumor relative to normal tissue. In most cancer types SCN9A is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where SCN9A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN9A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.922	<.001	12	view →
KIRC	Male	III,IV	+1.177	<.001	11	view →
HNSC	All	II,III,IV	+1.030	<.001	10	view →
READ	Female	All	−2.574	<.001	7	view →
BRCA	All	III,IV	−0.867	<.001	6	view →
UCEC	All	All	−0.308	.017	4	view →
STAD	Female	All	−0.864	.033	2	view →
KIRP	All	All	−0.553	.007	2	view →
LIHC	All	II,III,IV	−0.481	.015	2	view →
PRAD	All	All	−0.149	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SCN9A–COAD

Open the COAD breakdown →