SCN9A

Across TCGA cell cohorts, SCN9A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,073 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCN9A-associated GO terms across cancer lineages are ERAD pathway, Viral process, and Regulation of retrograde protein transport, ER to cytosol. Each is linked with SCN9A in more than 7 cancer types. Because this analysis shows association rather than direction, both SCN9A-to-partner and partner-to-SCN9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by SCN9A-low versus SCN9A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN9A→partner) and Y-score (partner→SCN9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ERAD pathway →	+0.055	+0.695	.004	.009	3	8
STOMACH	Viral process →	+0.075	+0.772	<.001	.002	3	6
SKIN	Regulation of retrograde protein transport, ER to cytosol →	+0.124	+0.707	<.001	.004	3	6
STOMACH	Regulation of programmed necrotic cell death →	+0.096	+1.159	<.001	<.001	3	6
BLOOD_Lymphoma	Oncostatin-M-mediated signaling pathway →	+0.118	+0.843	.003	.003	3	6
BLOOD_Lymphoma	Golgi to plasma membrane protein transport →	+0.076	+0.896	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,073 associations by consensus.

ERAD pathway by SCN9A expression — STOMACH

Explore this box plot interactively →