SCN9A

Across TCGA cell cohorts, SCN9A mutation is significantly associated with the RNA expression of many other genes, with 1,230 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN9A-associated genes across cancer lineages are MRPL2, RPS2, and TTLL8. Each is linked with SCN9A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN9A-to-partner and partner-to-SCN9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL2 grouped by SCN9A-low versus SCN9A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN9A→partner) and Y-score (partner→SCN9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRPL2 →	+0.336	+1.405	.006	.005	3	3
LARGE_INTESTINE	RPS2 →	+0.478	+2.222	<.001	.001	3	3
CNS	TTLL8 →	+0.007	+3.459	<.001	.006	3	2
URINARY_TRACT	CELA3A →	+0.077	+3.044	.001	.004	3	2
URINARY_TRACT	C18orf63 →	+0.014	+3.044	.009	.004	3	2
BREAST	OR51J1 →	+0.034	+3.672	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,230 associations by consensus.

MRPL2 by SCN9A expression — LARGE_INTESTINE

Explore this box plot interactively →