Across TCGA patient cohorts, SCN8A RNA expression is significantly associated with the protein abundance of many other proteins, with 14,646 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCN8A-associated proteins across cancer lineages are RALGAPB, SMARCC2_T322, and SP100_S18. Each is linked with SCN8A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN8A-to-partner and partner-to-SCN8A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN8A→partner) and Y-score (partner→SCN8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RALGAPB →	+0.211	+0.548	.002	<.001	3	4
LUAD	SMARCC2_T322 →	+1.131	+1.090	<.001	<.001	3	4
HNSC	SP100_S18 →	-0.348	-0.676	<.001	.001	3	4
LSCC	MYEF2 →	+0.995	+0.911	<.001	<.001	3	4
LSCC	NFKB1 →	-0.223	-0.727	<.001	<.001	3	4
HNSC	PLIN3 →	-0.372	-0.849	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,646 associations by consensus.

Exploration

SCN8A survival (RNA) · tumor vs normal (RNA) · all SCN8A data types