Across TCGA patient cohorts, SCN8A mutation is significantly associated with the RNA expression of many other genes, with 3,861 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN8A-associated genes across cancer lineages are RN7SL134P, UBE2M, and LINC01385. Each is linked with SCN8A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN8A-to-partner and partner-to-SCN8A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN8A→partner) and Y-score (partner→SCN8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL134P →	+0.074	+2.704	.003	.008	3	4
UCEC	UBE2M →	+0.239	+1.164	.002	.003	3	4
ACC	LINC01385 →	+0.437	+5.228	<.001	.005	3	3
COAD	BUB3 →	+0.339	+2.539	<.001	.008	3	3
LUAD	EME1 →	+0.684	+3.593	.001	.001	3	3
COAD	BEND7 →	-0.566	-2.558	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

Exploration

SCN8A survival (RNA) · tumor vs normal (RNA) · all SCN8A data types