Across TCGA patient cohorts, SCN8A mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN8A-associated genes across cancer lineages are Cyclin-E2, RAD51, and eEF2. Each is linked with SCN8A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN8A-to-partner and partner-to-SCN8A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN8A→partner) and Y-score (partner→SCN8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.201	+2.610	.016	.005	3	4
COAD	RAD51 →	+0.158	+2.459	.005	.017	3	4
COAD	eEF2 →	+0.303	+1.915	.004	.009	3	3
COAD	ASNS →	+0.547	+2.700	<.001	.005	3	3
COAD	Caspase-7-cleavedD198 →	+1.066	+3.807	<.001	<.001	3	3
UCEC	cIAP →	+0.095	+1.331	.009	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Exploration

SCN8A survival (RNA) · tumor vs normal (RNA) · all SCN8A data types