Across TCGA cell cohorts, SCN8A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,526 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCN8A-associated GO terms across cancer lineages are Establishment of protein localization to organelle, Negative regulation of gene expression, epigenetic, and Epigenetic regulation of gene expression. Each is linked with SCN8A in more than 14 cancer types. Because this analysis shows association rather than direction, both SCN8A-to-partner and partner-to-SCN8A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN8A→partner) and Y-score (partner→SCN8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.057	+0.843	<.001	.001	3	15
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.053	+0.862	<.001	<.001	3	13
URINARY_TRACT	Epigenetic regulation of gene expression →	+0.053	+1.431	<.001	.002	3	13
STOMACH	Negative regulation of myoblast fusion →	+0.120	+1.035	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.116	+0.889	.005	.005	3	12
BONE	Heterochromatin formation →	+0.067	+1.230	.005	.004	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,526 associations by consensus.

Exploration

SCN8A survival (RNA) · tumor vs normal (RNA) · all SCN8A data types