Across TCGA cell cohorts, SCN8A mutation is significantly associated with the RNA expression of many other genes, with 1,615 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN8A-associated genes across cancer lineages are CHIC2, SV2C, and CD1E. Each is linked with SCN8A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN8A-to-partner and partner-to-SCN8A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN8A→partner) and Y-score (partner→SCN8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHIC2 →	+0.389	+3.067	.007	.009	3	3
BLOOD_Leukemia	SV2C →	+0.244	+2.634	<.001	.005	3	2
URINARY_TRACT	CD1E →	+0.073	+3.584	.001	.009	3	2
URINARY_TRACT	ZNF716 →	+0.365	+3.584	<.001	.005	3	2
BLOOD_Leukemia	TNFSF8 →	+1.410	+4.087	.001	<.001	3	2
BLOOD_Leukemia	RNF165 →	+1.030	+3.259	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,615 associations by consensus.

Exploration

SCN8A survival (RNA) · tumor vs normal (RNA) · all SCN8A data types