Across TCGA cell cohorts, SCN8A mutation is significantly associated with the mutation status of many other genes, with 7,213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN8A-associated genes across cancer lineages are DNAH1, MYH6, and FSIP2. Each is linked with SCN8A in more than 6 cancer types. Because this analysis shows association rather than direction, both SCN8A-to-partner and partner-to-SCN8A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN8A→partner) and Y-score (partner→SCN8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNAH1 →	+2.538	+3.347	.005	.005	1	7
CNS	MYH6 →	+4.614	+4.614	.006	.006	1	6
OVARY	FSIP2 →	+2.667	+4.376	<.001	<.001	1	6
BREAST	KCNH3 →	+4.142	+2.857	.008	.008	1	6
BLOOD_Leukemia	UGT2A1 →	+4.665	+3.157	.003	.003	1	6
LARGE_INTESTINE	LAMA1 →	+2.479	+3.415	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,213 associations by consensus.

Exploration

SCN8A survival (RNA) · tumor vs normal (RNA) · all SCN8A data types