Across TCGA patient cohorts, SCN5A RNA expression is significantly associated with the protein abundance of many other proteins, with 13,259 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCN5A-associated proteins across cancer lineages are HNRNPH3, KIF1A_S1548, and LEMD2. Each is linked with SCN5A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN5A-to-partner and partner-to-SCN5A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN5A→partner) and Y-score (partner→SCN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HNRNPH3 →	+0.223	+0.363	.002	.003	3	5
LSCC	KIF1A_S1548 →	+3.328	+1.351	.004	.009	3	4
UCEC	LEMD2 →	+0.405	+1.497	.007	<.001	3	3
LSCC	PPP1R13L_S567 →	-0.550	-0.622	.004	<.001	3	3
OV	SAMSN1_S107 →	-0.968	-1.170	<.001	<.001	3	3
UCEC	TBX3_S456 →	+0.584	+1.239	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,259 associations by consensus.

Exploration

SCN5A survival (RNA) · tumor vs normal (RNA) · all SCN5A data types