Across TCGA patient cohorts, SCN5A mutation is significantly associated with the RNA expression of many other genes, with 7,885 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN5A-associated genes across cancer lineages are NDUFB6, SAAL1, and FBXO22. Each is linked with SCN5A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN5A-to-partner and partner-to-SCN5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN5A→partner) and Y-score (partner→SCN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NDUFB6 →	+0.377	+1.973	.007	.008	3	5
STAD	SAAL1 →	+0.493	+1.923	<.001	.009	3	5
UCEC	FBXO22 →	+0.436	+1.672	<.001	<.001	3	5
COAD	TIMM21 →	+0.454	+1.645	<.001	<.001	3	5
UCEC	KIF18A →	+0.423	+1.136	<.001	<.001	3	5
UCEC	AUNIP →	+0.501	+1.971	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,885 associations by consensus.

Exploration

SCN5A survival (RNA) · tumor vs normal (RNA) · all SCN5A data types