Across TCGA patient cohorts, SCN5A mutation is significantly associated with the total protein of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN5A-associated genes across cancer lineages are eEF2, FoxM1, and Lck. Each is linked with SCN5A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN5A-to-partner and partner-to-SCN5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN5A→partner) and Y-score (partner→SCN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.266	+1.716	.002	.002	3	4
STAD	FoxM1 →	+0.323	+2.201	.001	.031	3	3
STAD	Lck →	+0.279	+2.828	.014	.033	3	3
STAD	SF2 →	+0.278	+2.136	.043	.009	3	3
STAD	beta-Catenin →	+0.792	+2.115	.005	.017	3	3
STAD	c-Kit →	-0.353	-3.584	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

Exploration

SCN5A survival (RNA) · tumor vs normal (RNA) · all SCN5A data types