Across TCGA cell cohorts, SCN5A mutation is significantly associated with the RNA expression of many other genes, with 928 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN5A-associated genes across cancer lineages are OR5P2, FFAR3, and WARS2. Each is linked with SCN5A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN5A-to-partner and partner-to-SCN5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN5A→partner) and Y-score (partner→SCN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR5P2 →	+0.118	+4.392	<.001	.004	3	3
BLOOD_Myeloma	FFAR3 →	+0.028	+3.906	<.001	.009	3	3
CNS	WARS2 →	+0.621	+3.220	.001	.005	3	3
LARGE_INTESTINE	CTSS →	-1.758	-2.044	.002	.001	3	3
LARGE_INTESTINE	ACOT8 →	-0.479	-2.115	.004	.004	3	3
LARGE_INTESTINE	SART1 →	-0.361	-1.635	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 928 associations by consensus.

Exploration

SCN5A survival (RNA) · tumor vs normal (RNA) · all SCN5A data types