SCN4B

Across TCGA patient cohorts, SCN4B mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN4B-associated genes across cancer lineages are MEK1, Annexin-1, and VHL. Each is linked with SCN4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN4B-to-partner and partner-to-SCN4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SCN4B-low versus SCN4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4B→partner) and Y-score (partner→SCN4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.556	+3.459	.002	.005	3	2
UCEC	Annexin-1 →	+0.625	+2.827	.018	.035	3	2
UCEC	VHL →	-1.189	-3.000	<.001	.036	3	2
UCEC	Ku80 →	+0.250	+2.335	.035	.020	3	1
UCEC	Notch1 →	+0.195	+3.459	.005	.005	3	1
UCEC	PDK1_pS241 →	+0.175	+2.335	.041	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MEK1 by SCN4B expression — UCEC

Explore this box plot interactively →