SCN4B

Across TCGA pan-cancer cohorts, SCN4B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SCN4B data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SCN4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCN4B expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

UVM, KIRC, and BLCA are the cancer types where SCN4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.375	0.796	<.001	131	view →
KIRC	DFS	Median	All	0.709	0.548	<.001	119	view →
BLCA	OS	Median	All	0.307	0.566	<.001	74	view →
LUAD	OS	Quartile	II,III,IV	0.669	0.437	.001	42	view →
OV	OS	Quartile	II,III,IV	0.269	0.383	.004	42	view →
MESO	DFS	Tertile	All	0.446	0.274	.011	33	view →
ACC	DFS	Median	All	0.774	0.464	.004	23	view →
CHOL	DFS	Median	All	0.759	0.123	.004	21	view →
READ	OS	Median	III,IV	0.826	1.000	.014	20	view →
THCA	DFS	Median	All	0.899	0.764	<.001	18	view →
PAAD	OS	Quartile	II,III,IV	0.674	0.463	.014	16	view →
HNSC	DFS	Median	IV	0.434	0.311	.019	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SCN4B–UVM (DFS)

Open the UVM breakdown →