SCN4B

Across TCGA cell cohorts, SCN4B mutation is significantly associated with the mutation status of many other genes, with 1,517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN4B-associated genes across cancer lineages are PUS1, DIO3, and SOX18. Each is linked with SCN4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN4B-to-partner and partner-to-SCN4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PUS1 grouped by SCN4B-low versus SCN4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4B→partner) and Y-score (partner→SCN4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PUS1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	DIO3 →	+4.672	+5.329	<.001	<.001	1	2
LARGE_INTESTINE	SOX18 →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	PICK1 →	+5.672	+5.672	<.001	<.001	1	2
LARGE_INTESTINE	PRORP →	+4.672	+5.329	<.001	<.001	1	2
LARGE_INTESTINE	HBP1 →	+4.672	+5.329	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,517 associations by consensus.

PUS1 by SCN4B expression — LARGE_INTESTINE

Explore this box plot interactively →