SCN4A

Across TCGA pan-cancer cohorts, SCN4A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SCN4A data layer compared with 31 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SCN4A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCN4A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, ESCA, and LIHC are the cancer types where SCN4A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.489	0.635	.004	22	view →
ESCA	OS	Median	II,III,IV	0.440	0.714	<.001	21	view →
LIHC	OS	Median	II,III,IV	0.063	0.720	<.001	18	view →
COAD	DFS	Median	III,IV	0.185	0.703	.002	9	view →
LUSC	OS	Median	III,IV	0.117	0.717	.004	8	view →
GBM	DFS	Median	All	0.043	0.243	.003	6	view →
OV	OS	Median	II,III,IV	0.324	0.691	.049	6	view →
SCLC	DFS	Median	III,IV	0.192	0.556	.047	3	view →
UCEC	DFS	Median	II,III,IV	0.785	0.436	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SCN4A–SKCM (DFS)

Open the SKCM breakdown →