SCN3B

Across TCGA patient cohorts, SCN3B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN3B-associated genes across cancer lineages are ERK2, TFRC, and EGFR_pY1068. Each is linked with SCN3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN3B-to-partner and partner-to-SCN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SCN3B-low versus SCN3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3B→partner) and Y-score (partner→SCN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.245	+2.584	.001	.010	3	2
UCEC	TFRC →	+0.580	+1.906	.006	.016	3	2
UCEC	EGFR_pY1068 →	-0.305	-2.700	.002	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.108	-2.105	.030	.017	3	1
UCEC	GAPDH →	+0.470	+2.999	.029	.035	3	1
UCEC	ACC1 →	+0.337	+2.000	.021	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ERK2 by SCN3B expression — UCEC

Explore this box plot interactively →