SCN3B

Across TCGA cell cohorts, SCN3B mutation is significantly associated with the drug of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN3B-associated genes across cancer lineages are AGI-6780, 50869, and Ispinesib Mesylate. Each is linked with SCN3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN3B-to-partner and partner-to-SCN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGI-6780 grouped by SCN3B-low versus SCN3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3B→partner) and Y-score (partner→SCN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.378	+2.868	.039	.022	3	1
LARGE_INTESTINE	50869 →	+0.479	+2.871	.016	.021	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.768	+2.874	.012	.021	3	1
LARGE_INTESTINE	SU11274 →	+0.545	+2.874	.004	.021	3	1
LARGE_INTESTINE	CD532 →	+0.390	+2.874	.041	.021	3	1
LARGE_INTESTINE	CP466722 →	+0.473	+2.874	.010	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

AGI-6780 by SCN3B expression — LARGE_INTESTINE

Explore this box plot interactively →