SCN3A

Across TCGA pan-cancer cohorts, SCN3A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SCN3A data layer compared with 29 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SCN3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCN3A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, UCEC, and READ are the cancer types where SCN3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	II,III,IV	0.906	0.295	.003	30	view →
READ	OS	Median	IV	0.111	0.893	<.001	24	view →
BRCA	OS	Median	IV	0.106	0.791	<.001	12	view →
ACC	OS	Median	All	0.159	0.623	.017	12	view →
ESCA	OS	Median	II,III,IV	0.452	0.713	.016	9	view →
LIHC	OS	Median	II,III,IV	0.010	0.697	<.001	9	view →
THCA	OS	Median	All	0.277	0.954	<.001	6	view →
BLCA	OS	Median	IV	0.074	0.599	<.001	6	view →
LUSC	OS	Median	II,III,IV	0.506	0.741	.018	4	view →
SCLC	OS	Median	All	0.405	0.783	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SCN3A–THYM (OS)

Open the THYM breakdown →