SCN3A

Across TCGA pan-cancer cohorts, SCN3A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SCN3A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SCN3A RNA is repressed in tumor relative to normal tissue. In most cancer types SCN3A is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where SCN3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.586	<.001	12	view →
THCA	Male	III,IV	−1.028	<.001	11	view →
KIRC	Female	All	−0.731	<.001	10	view →
KICH	Male	All	−0.687	<.001	10	view →
BRCA	Female	II,III,IV	−1.332	<.001	6	view →
KIRP	All	All	−0.542	<.001	6	view →
UCEC	All	III,IV	−0.474	<.001	6	view →
STAD	Male	III,IV	−0.396	.011	5	view →
BLCA	All	All	−0.284	.018	5	view →
LUSC	All	III,IV	−0.285	.010	3	view →
HNSC	Female	III,IV	+0.215	.009	3	view →
READ	All	All	−0.711	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SCN3A–COAD

Open the COAD breakdown →