SCN3A

Across TCGA patient cohorts, SCN3A mutation is significantly associated with the RNA expression of many other genes, with 7,002 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN3A-associated genes across cancer lineages are MRPS5, UBE2T, and CCNB1. Each is linked with SCN3A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN3A-to-partner and partner-to-SCN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS5 grouped by SCN3A-low versus SCN3A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3A→partner) and Y-score (partner→SCN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPS5 →	+0.276	+2.295	.003	.001	3	5
UCEC	UBE2T →	+0.570	+1.690	<.001	<.001	3	5
UCEC	CCNB1 →	+0.660	+1.777	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.632	+1.788	<.001	<.001	3	4
STAD	MIR3122 →	+0.572	+2.686	<.001	.002	3	4
UCEC	KPNA2 →	+0.460	+1.404	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,002 associations by consensus.

MRPS5 by SCN3A expression — LUAD

Explore this box plot interactively →