SCN3A

Across TCGA patient cohorts, SCN3A mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN3A-associated genes across cancer lineages are Cyclin-B1, MYH11, and PCNA. Each is linked with SCN3A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN3A-to-partner and partner-to-SCN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SCN3A-low versus SCN3A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3A→partner) and Y-score (partner→SCN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.740	+3.000	.001	.034	2	5
LUSC	MYH11 →	-1.191	-2.078	<.001	.005	3	4
UCEC	PCNA →	+0.189	+1.700	<.001	<.001	3	4
COAD	MIG-6 →	+0.086	+1.737	.011	.012	3	4
STAD	ER-alpha →	-0.182	-3.148	.031	.019	3	3
BLCA	Caspase-7-cleavedD198 →	+0.594	+2.999	.027	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Cyclin-B1 by SCN3A expression — STAD

Explore this box plot interactively →