SCN3A

Across TCGA cell cohorts, SCN3A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,483 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCN3A-associated GO terms across cancer lineages are Spindle organization, Centriole-centriole cohesion, and Regulation of autophagosome maturation. Each is linked with SCN3A in more than 5 cancer types. Because this analysis shows association rather than direction, both SCN3A-to-partner and partner-to-SCN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle organization grouped by SCN3A-low versus SCN3A-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3A→partner) and Y-score (partner→SCN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Spindle organization →	+0.046	+0.781	<.001	<.001	3	6
BLOOD_Leukemia	Centriole-centriole cohesion →	+0.060	+0.767	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of autophagosome maturation →	+0.086	+0.120	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of post-translational protein modification →	+0.047	+0.075	<.001	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of brown fat cell differentiation →	+0.122	+0.100	<.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of nucleotide-excision repair →	+0.074	+0.058	.006	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,483 associations by consensus.

Spindle organization by SCN3A expression — BLOOD_Leukemia

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