SCN3A

Across TCGA cell cohorts, SCN3A mutation is significantly associated with the RNA expression of many other genes, with 698 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN3A-associated genes across cancer lineages are ZRSR2, KCNAB3, and PRB2. Each is linked with SCN3A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN3A-to-partner and partner-to-SCN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZRSR2 grouped by SCN3A-low versus SCN3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3A→partner) and Y-score (partner→SCN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZRSR2 →	+0.465	+3.285	.007	.004	3	3
LARGE_INTESTINE	KCNAB3 →	+0.738	+3.584	<.001	<.001	3	3
BLOOD_Leukemia	PRB2 →	+0.081	+2.070	.001	.008	3	2
BLOOD_Leukemia	NKX2-6 →	+0.146	+2.879	.004	.001	3	2
BLOOD_Leukemia	PRR30 →	+0.007	+2.362	.001	.007	3	2
OVARY	IFNA2 →	+0.015	+4.807	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 698 associations by consensus.

ZRSR2 by SCN3A expression — BLOOD_Leukemia

Explore this box plot interactively →