SCN2B

Across TCGA patient cohorts, SCN2B mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN2B-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and EGFR_pY1173. Each is linked with SCN2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN2B-to-partner and partner-to-SCN2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SCN2B-low versus SCN2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2B→partner) and Y-score (partner→SCN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.484	-3.000	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.338	-2.321	.001	.006	3	1
UCEC	EGFR_pY1173 →	+0.071	+1.833	.031	.016	3	1
UCEC	GAPDH →	+0.536	+1.807	.015	.027	3	1
UCEC	GATA6 →	-0.170	-2.584	.007	.010	3	1
UCEC	JNK2 →	+0.296	+2.469	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

STAT3_pY705 by SCN2B expression — UCEC

Explore this box plot interactively →