SCN2A

Across TCGA patient cohorts, SCN2A RNA expression is significantly associated with the protein abundance of many other proteins, with 14,423 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCN2A-associated proteins across cancer lineages are PURA, SMOC1, and SYNPO. Each is linked with SCN2A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN2A-to-partner and partner-to-SCN2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCN2A versus PURA in UCEC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2A→partner) and Y-score (partner→SCN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PURA →	+0.367	+0.844	<.001	<.001	3	3
GBM	SMOC1 →	+1.174	+0.806	<.001	<.001	3	3
GBM	SYNPO →	+0.343	+0.981	.003	<.001	3	3
GBM	ARHGAP30_S709 →	-0.795	-0.951	.001	<.001	3	3
OV	PLS3 →	+0.818	+0.419	<.001	.005	3	3
PDAC	RRP1 →	-0.251	-0.419	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,423 associations by consensus.

SCN2A vs PURA — UCEC

Explore this scatter interactively →