SCN2A

Across TCGA pan-cancer cohorts, SCN2A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SCN2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCN2A RNA is repressed in tumor relative to normal tissue. In most cancer types SCN2A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where SCN2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.694	<.001	12	view →
KICH	All	All	−0.909	<.001	11	view →
BRCA	All	III,IV	−1.271	<.001	6	view →
UCEC	All	All	−0.540	<.001	6	view →
HNSC	All	All	+0.283	.016	6	view →
KIRP	Male	All	−1.065	<.001	4	view →
LUSC	All	All	+0.376	.003	4	view →
LUAD	All	II,III,IV	−0.112	.004	4	view →
CHOL	All	All	+0.241	.012	2	view →
THCA	All	II,III,IV	−0.023	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SCN2A–KIRC

Open the KIRC breakdown →