SCN2A

Across TCGA patient cohorts, SCN2A protein abundance is significantly associated with the RNA expression of many other genes, with 3,562 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCN2A-associated genes across cancer lineages are PRODH, GRK3, and SEZ6L. Each is linked with SCN2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN2A-to-partner and partner-to-SCN2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCN2A versus PRODH in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2A→partner) and Y-score (partner→SCN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.912	+0.649	<.001	<.001	3	1
GBM	GRK3 →	+0.572	+0.757	.001	.001	3	1
GBM	SEZ6L →	+1.200	+0.529	.001	<.001	3	1
GBM	SOX10 →	+1.456	+0.934	<.001	<.001	3	1
GBM	SLC16A8 →	+0.767	+0.837	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.982	+0.840	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,562 associations by consensus.

SCN2A vs PRODH — GBM

Explore this scatter interactively →