SCN2A

Across TCGA patient cohorts, SCN2A mutation is significantly associated with the RNA expression of many other genes, with 7,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN2A-associated genes across cancer lineages are PRC1, CCNA2, and OIP5. Each is linked with SCN2A in more than 5 cancer types. Because this analysis shows association rather than direction, both SCN2A-to-partner and partner-to-SCN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRC1 grouped by SCN2A-low versus SCN2A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2A→partner) and Y-score (partner→SCN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRC1 →	+0.686	+3.807	<.001	<.001	3	6
UCEC	CCNA2 →	+0.659	+1.534	<.001	<.001	3	6
UCEC	OIP5 →	+0.717	+1.799	<.001	<.001	3	5
UCEC	CCNB1 →	+0.680	+1.914	<.001	<.001	3	5
COAD	SHROOM4 →	-0.804	-2.087	<.001	.005	3	5
UCEC	PTTG1 →	+0.521	+1.289	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,106 associations by consensus.

PRC1 by SCN2A expression — LUAD

Explore this box plot interactively →