SCN2A

Across TCGA patient cohorts, SCN2A mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN2A-associated genes across cancer lineages are ASNS, 4E-BP1, and GAPDH. Each is linked with SCN2A in more than 6 cancer types. Because this analysis shows association rather than direction, both SCN2A-to-partner and partner-to-SCN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SCN2A-low versus SCN2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2A→partner) and Y-score (partner→SCN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.488	+3.000	.001	.034	3	7
LUAD	4E-BP1 →	+0.357	+3.392	<.001	<.001	3	5
UCEC	GAPDH →	+0.423	+1.716	.001	.002	3	5
UCEC	Caspase-7-cleavedD198 →	+0.814	+1.700	<.001	<.001	3	5
STAD	FASN →	+0.434	+2.459	.016	.019	3	4
LUAD	TFRC →	+0.462	+3.169	.012	.018	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

ASNS by SCN2A expression — COAD

Explore this box plot interactively →