SCN2A

Across TCGA cell cohorts, SCN2A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,747 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SCN2A-associated GO terms across cancer lineages are Monocarboxylic acid transport, Cellular response to ether, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with SCN2A in more than 5 cancer types. Because this analysis shows association rather than direction, both SCN2A-to-partner and partner-to-SCN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocarboxylic acid transport grouped by SCN2A-low versus SCN2A-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2A→partner) and Y-score (partner→SCN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Monocarboxylic acid transport →	-0.052	-0.411	.004	.005	3	6
CNS	Cellular response to ether →	-0.099	-0.590	.007	.007	3	5
SKIN	Regulation of syncytium formation by plasma membrane fusion →	+0.077	+0.471	<.001	.001	3	5
SKIN	Establishment of protein localization to membrane →	+0.053	+0.697	<.001	.001	3	5
STOMACH	Negative regulation of post-translational protein modification →	+0.070	+1.042	.002	.005	2	6
BLOOD_Lymphoma	Response to type I interferon →	+0.094	+0.527	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,747 associations by consensus.

Monocarboxylic acid transport by SCN2A expression — SKIN

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