SCN2A

Across TCGA cell cohorts, SCN2A mutation is significantly associated with the RNA expression of many other genes, with 1,276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN2A-associated genes across cancer lineages are PPP1R2C, SSX3, and SLC2A7. Each is linked with SCN2A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN2A-to-partner and partner-to-SCN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2C grouped by SCN2A-low versus SCN2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2A→partner) and Y-score (partner→SCN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R2C →	+0.086	+2.954	.001	.005	3	3
SOFT_TISSUE	SSX3 →	+1.636	+4.635	<.001	.003	3	2
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	2
BLOOD_Myeloma	MRGPRG →	+0.054	+3.700	<.001	<.001	3	2
STOMACH	OR52I2 →	+0.016	+4.339	<.001	.003	3	2
BLOOD_Leukemia	NEUROD4 →	+0.022	+2.206	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,276 associations by consensus.

PPP1R2C by SCN2A expression — BLOOD_Leukemia

Explore this box plot interactively →