SCN1B

Across TCGA patient cohorts, SCN1B mutation is significantly associated with the RNA expression of many other genes, with 394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN1B-associated genes across cancer lineages are RNU6-1292P, SNORD116-10, and RNU6-1138P. Each is linked with SCN1B in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN1B-to-partner and partner-to-SCN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1292P grouped by SCN1B-low versus SCN1B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1B→partner) and Y-score (partner→SCN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1292P →	+0.228	+4.884	<.001	.004	3	4
SKCM	SNORD116-10 →	+0.297	+5.039	<.001	.003	3	2
COAD	RNU6-1138P →	+1.023	+5.375	<.001	<.001	3	2
CESC	TRIM64EP →	+0.040	+4.384	<.001	.008	3	2
CESC	LINC00376 →	+0.180	+3.705	<.001	.008	3	2
COAD	RNA5SP165 →	+0.673	+4.665	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 394 associations by consensus.

RNU6-1292P by SCN1B expression — SKCM

Explore this box plot interactively →